"Il Cascinale" is reached from Milan to Bologna A1
then A14 direction Ancona exit Cesena;

Rome to take E45 direction Assisi - Foligno output
Santa Maria degli Angeli Nord.

From Rome A1 direction Florence exit Orte,
then take the E45 towards Perugia, Assisi direction
Foligno, exit at Santa Maria degli Angeli Nord.